Radiopharmaceutical
CMIT is engaged in radiopharmaceutical science research. Specifically, the team has the experience and expertise to optimize radiochemistry synthesis, develop novel radiopharmaceuticals, and perform large scale production of molecular imaging probes. CMIT’s manufacturing, and distribution facilities, provide radiopharmaceuticals for clinical and research applications.
Available Radiopharmaceuticals
CMIT has many other radiopharmaceuticals in our library that are not included here. CMIT can customize radiopharmaceuticals for specific needs. Please inquire, if interested.
- F-18 Fludeoxglucose (FDG)
- F-18 Fluorothymidine (FLT)
- F-18 Fluorodopa (F-DOPA)
- F-18 Sodium Fluoride (NaF)
- N-13 Ammonia
- F-18 AV1451
- F-18 AV133
Services
Production
CMIT has an IBA Cyclone 18 and a newly installed GE PETTrace 860. Both machines are capable of producing curie-levels of relevant isotopes for daily manufacturing and research needs.
Quality Control
All CMIT products undergo rigorous quality control and quality assurance testing. Each radiopharmaceutical has strict acceptance criteria defined during the development process and our QA procedures ensure adherence to those criteria. All quality control procedures are performed in dedicated quality control laboratories.
Manufacturing
CMIT has many different radiopharmaceutical synthesizers capable of manufacturing both clinical and research grade radiopharmaceuticals under GMP and non-GMP conditions. These synthesizers produce high quality radiopharmaceuticals. CMIT’s highly trained staff is capable of developing procedures and implementing them on a daily basis. They also provide contract manufacturing capabilities for organizations looking for such services.
Hot Cells
CMIT has multiple mini cells for routine manufacturing purposes as well as full research grade hot cells for novel and custom manufacturing and development work. These state of the art hot cells provide capacity for the daily manufacturing needs as well as significant research efforts.
Clean Room
CMIT’s clean rooms ensure all products are manufactured in an aseptic manner to maintain the sterility of the product. CMIT staff are trained in clean room operations with SOPs designed to maintain the integrity of the clean rooms.
Distribution
CMIT has a well-designed and efficient distribution network, regularly transporting routine and boutique clinical and research radiopharmaceuticals by road and by air.
Radiopharmaceutical Facilities
CMIT radiopharmaceutical facilities encompass multiple laboratories that house highly technical equipment and highly trained researchers and technicians. These facilities include isotope production, radiopharmaceutical manufacturing, quality control, and research laboratories as well as the dedicated equipment such as hot cells, synthesizers and clean rooms necessary to produce high quality radiopharmaceuticals and perform high quality research.
Radiochemistry Research Lab
The Radiochemistry Research Lab is where the development of novel radiopharmaceuticals and method optimization and development occurs. Researchers work to develop new radiolabeling techniques and to refine and create already known methods for radiopharmaceutical manufacturing. This lab also houses quality control equipment used as part of the research program.
Manufacturing Facilities
CMIT’s manufacturing facility provides GMP-compliant radiopharmaceuticals. Resources include multiple mini-cells, hot cells, synthesizers and routine quality control equipment. These resources provide CMIT with significant capacity when it comes to radiopharmaceutical manufacturing.
Quality Control & Quality Assurance Labs
CMIT’s QC capabilities include specific activity, radiochemical purity, chemical purity, toxicity, sterility and pH via GC, HPLC, TLC, and other QC equipment. Radiochemists and chemists perform daily QC testing as well as the instrument certification and qualification and SOP development.
Cyclotron Facilities
CMIT houses two cyclotrons which are machines used to produce radioactive isotopes for radiopharmaceutical manufacturing.
Clean Rooms
CMIT has clean rooms which ensure that all products are manufactured aseptically and that sterility of the final product is maintained. The clean rooms are maintained by highly trained staff and are maintained appropriately.
Chemical Labs
CMIT has multiple chemistry labs where medicinal and organic chemistry research and functions are performed. Researchers use these labs to engage in new compound and molecule development and synthesis as well as other chemistry related work.
Research and Development
CMIT focuses on research and development. Our core competency is developing novel radiopharmaceuticals and improving on current tools and procedures. Rather than keeping up with science, CMIT creates it.
Research Examples
Developing New Chemistry
Developing novel Radio-Labeling Methods
Radiochemistry Optimization
Developing Novel Radiopharmaceuticals
At CMIT, the quest to develop a radiopharmaceutical begins with a biologic question or medical condition. Researchers work to identify how to answer a scientific question, diagnose a disease, or evaluate therapeutic efficacy. These researchers develop new compounds and molecules with potential to increase the knowledge of molecular processes. After years of work, a radiopharmaceutical that impacts the healthcare of a sufferer of a particular ailment is hopefully produced.